The Botanical Garden of D.M. College of Science was established in 1986 when Dr. D.S. Sharma was serving as the principal of the college. The principal assigned the task of the supervision of the garden to Dr. H. Nandiram Sharma, Former Head of Department of Botany. The Garden is still a part of ex-situ conservation of exotic and local indigenous plant species of medicinal and ethnobotanical aspects under Department of Botany. The garden is located in the eastern part of the college occupying 1.16 hectare of land.      After a long gap of 20 years, Ministry of Environment and Forests, Government of India had given a financial assistance on the 15th May, 2006 for improvement and infrastructure development of the garden towards a project proposal submitted by Dr. Elangbam Jadu Singh, former Reader, Department of Botany, D. M. College of Science, Imphal and now the Principal of the college.

Plantation of some exotic and indigenous local shrub and tree species was launched in the month of May 2006 to meet the objective of Ministry of Environment and Forests. The actual system of a garden was not developed before the implementation of the project and the garden itself looked like a man made savanna (i.e. vast grassland with scattered trees) due to improper maintenance before 2006. At present, in course of time, the garden is changing to forest from the woodland with the continuous plantation of saplings since 2006. With the financial assistance from the Ministry of Environment and Forests, Government of India, three important infrastructures could be constructed in the garden, viz. one green shed (40ft x 16.6 ft), one garden shed (10 ft. diameter) and one lawn (52ft  x 24 ft).

            Besides infrastructure development, 246 plants belonging to 82 genera of rare, endangered and threatened plant species relating to aspect of medicine, aromatic and dye have been conserved properly in the garden under the financial assistance of Ministry of Environment and Forests. However, some exotic and local plant species belonging to 18 genera had been conserving in the garden before 2006.  Some of the endangered plant species conserving in the garden are Aegle mormolus, (Harikhagok), Amoora rohituka (Heirangoi), Averrhoea carambola (Heinaoujom), Aquilaria agallocha (Agar) Bixa orellana (Ureirom), Butea monosperma (Pangong), Flacourtia jangomas (Haitroi), Garcinia xytho chymus(Heibung), Grateiva reiglosa (Loyumba), Oryxylon indica ( Samba), Premna mucronata (U-ngou) , Quercus pachyphylla (Kuhi), Sapindus mukorossi (KeKru), Symplococas paniculata (Leiree), Terminalia arjuna (Mayokpha,) Terminalia chebula (Manahi) , Phlogacanthers jekancia (Nongmangkha Ashinba) and Xanthoxylum budrunga (Ngang). The garden is now managed under the strict supervision of Dr. Elangbam Jadu Singh, Principal, D. M. College of Science. It will provide a vivid glimpse of endemic and rare species of the plant world. Further, it is also worth notable that as of now, this is the biggest Botanical Garden owned by a Government College and one of the precious properties of the State of Manipur.